Post List

  • April 28, 2015
  • 02:44 PM

The adolescent brain on alcohol: Changes last into adulthood

by Dr. Jekyll in Lunatic Laboratories

Repeated alcohol exposure during adolescence results in long-lasting changes in the region of the brain that controls learning and memory, according to a research team at Duke Medicine that used a rodent model as a surrogate for humans. The study provides new insights at the cellular level for how alcohol exposure during adolescence, before the brain is fully developed, can result in cellular and synaptic abnormalities that have enduring, detrimental effects on behavior.... Read more »

Risher, M., Fleming, R., Risher, W., Miller, K., Klein, R., Wills, T., Acheson, S., Moore, S., Wilson, W., Eroglu, C.... (2015) Adolescent Intermittent Alcohol Exposure: Persistence of Structural and Functional Hippocampal Abnormalities into Adulthood. Alcoholism: Clinical and Experimental Research. DOI: 10.1111/acer.12725  

  • April 28, 2015
  • 11:35 AM

Snowshoe Hares Pass Down Stress to Multiple Future Generations

by Elizabeth Preston in Inkfish

It's hard to be a showshoe hare. The northern animals are in a constant race for survival with their predators, always cycling between population booms and busts. In hard years, hares are understandably stressed. And that stress can leave its signature not just on those animals, but on several future generations.

When life is good, populations of showshoe hares (Lepus americanus) can roughly double every year. But the hare's predators—lynx, foxes, coyotes—also increase in numbers as ........ Read more »

  • April 28, 2015
  • 11:10 AM

Chilesaurus diegosuarezi, T-rex’s Vegetarian Cousin

by beredim in Strange Animals

Chilesaurus diegosuarezi
Artistic interpretation
Credit: Gabriel Lío

Researchers announced yesterday the discovery of a new dinosaur that although closely related to the carnivorous T-Rex it preferred to feed on plant material. The new lineage of dinosaur was discovered in Chile and has proven to be an evolutionary jigsaw puzzle.

Paleontologists are referring to the newly described species (... Read more »

Novas, F., Salgado, L., Suárez, M., Agnolín, F., Ezcurra, M., Chimento, N., de la Cruz, R., Isasi, M., Vargas, A., & Rubilar-Rogers, D. (2015) An enigmatic plant-eating theropod from the Late Jurassic period of Chile. Nature. DOI: 10.1038/nature14307  

  • April 28, 2015
  • 09:40 AM

Murder Your Darling Hypotheses But Do Not Bury Them

by Jalees Rehman in The Next Regeneration

There is surprisingly little data on how and when scientists reject hypotheses, but John Fugelsang and Kevin Dunbar at Dartmouth conducted a rather unique study "Theory and data interactions of the scientific mind: Evidence from the molecular and the cognitive laboratory" in 2004 in which they researched researchers. They sat in at scientific laboratory meetings of three renowned molecular biology laboratories at carefully recorded how scientists presented their laboratory data and how........ Read more »

Fugelsang, J., Stein, C., Green, A., & Dunbar, K. (2004) Theory and Data Interactions of the Scientific Mind: Evidence From the Molecular and the Cognitive Laboratory. Canadian Journal of Experimental Psychology/Revue canadienne de psychologie expérimentale, 58(2), 86-95. DOI: 10.1037/h0085799  

  • April 28, 2015
  • 08:00 AM

Quicksilver: The Avenger With Mutations For Speed

by Mark E. Lasbury in The 'Scope

The New Avengers movie comes out in a couple days. In this film, a new Avenger named Quicksilver makes his debut. Quicksilver is a mutant who can run fast – really fast. What mutation could make him that fast? Well, science has found several gene changes he might use to become a superhero.... Read more »

Reyes, N., Banks, G., Tsang, M., Margineantu, D., Gu, H., Djukovic, D., Chan, J., Torres, M., Liggitt, H., Hirenallur-S, D.... (2015) Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy. Proceedings of the National Academy of Sciences, 112(2), 424-429. DOI: 10.1073/pnas.1413021112  

Potter, M., Wyble, B., Hagmann, C., & McCourt, E. (2013) Detecting meaning in RSVP at 13 ms per picture. Attention, Perception, , 76(2), 270-279. DOI: 10.3758/s13414-013-0605-z  

  • April 28, 2015
  • 07:03 AM

Mind-blowing Brain Cases: The Woman With Half A Brain

by Elisabeth Buhl Thubron in United Academics

Chinese woman without a cerebellum gives insight into neuroplasticity.... Read more »

  • April 28, 2015
  • 04:36 AM

Melatonin and leaky gut continued

by Paul Whiteley in Questioning Answers

The paper from Garth Swanson and colleagues [1] reporting findings suggesting that "suppression of melatonin in AD [alcohol use disorder] may promote gut leakiness and endotoxemia" make for the discussion point today.Continuing a theme from previous times on this blog that "melatonin may serve important gastrointestinal barrier functions" [2] and specifically those related to the concept of intestinal permeability and the so-called 'leaky gut' (see here), these are potentially imp........ Read more »

Swanson GR, Gorenz A, Shaikh M, Desai V, Forsyth CB, Fogg L, Burgess HJ, & Keshavarzian A. (2015) Decreased Melatonin Secretion is Associated with Increased Intestinal Permeability and Marker of Endotoxemia in Alcoholics. American journal of physiology. Gastrointestinal and liver physiology. PMID: 25907689  

  • April 27, 2015
  • 08:32 PM

A bacterium that loves Roman mythology, sharing with worms, and playing with nitrogen

by Rosin Cerate in Rosin Cerate

Opitutus terrae is a bacterium found in rice paddy soil. It's well suited to this environment, being able to operate without oxygen (rice paddies are flooded with water, limiting the movement of gases from the atmosphere into the soil) and capable of eating chains of sugar made by rice plants (which are introduced into the soil when paddies are plowed at the end of a harvest). O. terrae was first isolated from a rice paddy in Vercelli, a city in northern Italy. Vercelli is situated in the Po Val........ Read more »

  • April 27, 2015
  • 02:03 PM

Google searches for ‘n-word’ associated with black mortality

by Dr. Jekyll in Lunatic Laboratories

Google searches could unveil patterns in Black mortality rates across the US, according to a new study. Researchers found that those areas with greater levels of racism, as indexed by the proportion of Google searches containing the “n-word,” had higher mortality rates among Blacks. The study is the first to examine an Internet query-based measure of racism in relation to mortality risk.... Read more »

Chae, D., Clouston, S., Hatzenbuehler, M., Kramer, M., Cooper, H., Wilson, S., Stephens-Davidowitz, S., Gold, R., & Link, B. (2015) Association between an Internet-Based Measure of Area Racism and Black Mortality. PLOS ONE, 10(4). DOI: 10.1371/journal.pone.0122963  

  • April 27, 2015
  • 01:39 PM

Parasite-Infected Bumblebees Seek out Flowers with Nicotine

by beredim in Strange Animals

 A buff-tailed bumblebee (Bombus terrestris

Buff-tailed bumblebees (Bombus terrestris) that have been infected by parasites seek out flowers with nicotine in their nectar, according to a new study by researchers at the Royal Holloway University of London and Queen Mary University of London, UK.

Apparently, the nicotine in the flowers slows the progression of disease in infected bees but has ... Read more »

  • April 27, 2015
  • 12:28 PM

Boron and the Permian extinction: a glimpse into the past gives a hint of the future

by Jonathan Trinastic in Goodnight Earth

How will ocean acidification from anthropogenic CO2 emissions affect marine life? Recent work studying a similar time during the Permian extinction 200 million years ago gives a clue.... Read more »

Clarkson MO, Kasemann SA, Wood RA, Lenton TM, Daines SJ, Richoz S, Ohnemueller F, Meixner A, Poulton SW, & Tipper ET. (2015) Ocean acidification and the Permo-Triassic mass extinction. Science (New York, N.Y.), 348(6231), 229-32. PMID: 25859043  

  • April 27, 2015
  • 10:50 AM

ADHD and Vehicular Accident Risk

by William Yates, M.D. in Brain Posts

Attention and impulsive behaviors found in attention deficit hyperactivity disorder (ADHD) can contribute to accident risk in children and adults.A recent study of adult drivers in France provides evidence for increased accident risk in adults with ADHD.Researchers at the Bordeaux University Hospital interviewed a series of adult drivers seen in the emergency department following a road traffic crash.A total of 777 eligible subjects completed assessments of accident information, distraction expo........ Read more »

  • April 27, 2015
  • 08:34 AM

Phytozome notice, new and improved v10 coming soon

by Mary in OpenHelix

This announcement came out while I was at a conference last week–but I wanted to pass it along. This appears to be a big change in the way Phytozome works. And there will be down-time before it rolls out, starting May 1. I like to post major announcements from mailing lists because I know everyone […]... Read more »

Goodstein D. M., R. Howson, R. Neupane, R. D. Hayes, J. Fazo, T. Mitros, W. Dirks, U. Hellsten, N. Putnam, & D. S. Rokhsar. (2011) Phytozome: a comparative platform for green plant genomics. Nucleic Acids Research, 40(D1). DOI:  

  • April 27, 2015
  • 07:00 AM

Role of EBV LMP-2A and LMP1 in inducing autophagy

by thelonevirologist in Virology Tidbits

Under conditions of cell stress such as nutrient deprivation or as a result of the accumulation of damaged organelles and misfolded proteins a lysosomal pathway is induced which degrades proteins as well organelles independent of the proteasomal pathway. The core machinery of this pathway -termed autophagy from the Greek  auto-, "self" and phagein, "to eat” (literally “selfeating”) - was discovered in genetic screens of yeast for genes required for survival ........ Read more »

Xi X, Zhang X, Wang B, Wang T, Wang J, Huang H, Wang J, Jin Q, & Zhao Z. (2013) The interplays between autophagy and apoptosis induced by enterovirus 71. PloS one, 8(2). PMID: 23437282  

Liu Y, & Levine B. (2015) Autosis and autophagic cell death: the dark side of autophagy. Cell death and differentiation, 22(3), 367-76. PMID: 25257169  

Liu Y, Shoji-Kawata S, Sumpter RM Jr, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ.... (2013) Autosis is a Na ,K -ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20364-71. PMID: 24277826  

Young, L., & Rickinson, A. (2004) Epstein–Barr virus: 40 years on. Nature Reviews Cancer, 4(10), 757-768. DOI: 10.1038/nrc1452  

Busson P, McCoy R, Sadler R, Gilligan K, Tursz T, & Raab-Traub N. (1992) Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma. Journal of virology, 66(5), 3257-62. PMID: 1313931  

Li Y, Zhang L, Zhou J, Luo S, Huang R, Zhao C, & Diao A. (2015) Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy. Cell proliferation. PMID: 25809873  

Kuang E, Qi J, & Ronai Z. (2013) Emerging roles of E3 ubiquitin ligases in autophagy. Trends in biochemical sciences, 38(9), 453-60. PMID: 23870665  

Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z.... (2013) WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. The EMBO journal, 32(20), 2685-96. PMID: 23974797  

  • April 27, 2015
  • 04:36 AM

When optimal outcome in autism meets ESSENCE

by Paul Whiteley in Questioning Answers

I recently came across the paper by Martina Barnevik Olsson and colleagues [1] (open-access) and their rather interesting take on the issue of optimal outcome and autism (see here for some background on this concept).Based on the idea that a diagnosis of autism or autism spectrum disorder (ASD) might not be as immutable as perhaps once thought (as in 'no longer meeting the diagnostic criteria for the condition'), Barnevik Olsson et al reported that loss of the autism/ASD label does not........ Read more »

Barnevik Olsson, M., Westerlund, J., Lundström, S., Giacobini, M., Fernell, E., & Gillberg, C. (2015) “Recovery” from the diagnosis of autism – and then?. Neuropsychiatric Disease and Treatment, 999. DOI: 10.2147/NDT.S78707  

  • April 27, 2015
  • 12:05 AM

As if Sustaining a TBI was not Enough….TBI May Accelerate Brain Aging

by Jane McDevitt in Sports Medicine Research (SMR): In the Lab & In the Field

A patient with a moderate or severe traumatic brain injury is likely to have structural brain changes that are associated with an older brain than his/her actual age.... Read more »

Cole JH, Leech R, Sharp DJ, & Alzheimer's Disease Neuroimaging Initiative. (2015) Prediction of brain age suggests accelerated atrophy after traumatic brain injury. Annals of Neurology, 77(4), 571-81. PMID: 25623048  

  • April 26, 2015
  • 11:53 PM

FDA says no to marketing FDDNP for CTE

by The Neurocritic in The Neurocritic

The U.S. Food and Drug Administration recently admonished TauMark™, a brain diagnostics company, for advertising brain scans that can diagnose chronic traumatic encephalopathy (CTE), Alzheimer's disease, and other types of dementia. The Los Angeles Times reported that the FDA ordered UCLA researcher Dr. Gary Small and his colleague/business partner Dr. Jorge Barrio to remove misleading information from their company website (example shown below).CTE has been in the news because the neurodegene........ Read more »

Barrio, J., Small, G., Wong, K., Huang, S., Liu, J., Merrill, D., Giza, C., Fitzsimmons, R., Omalu, B., Bailes, J.... (2015) In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging. Proceedings of the National Academy of Sciences, 201409952. DOI: 10.1073/pnas.1409952112  

Zimmer, E., Leuzy, A., Gauthier, S., & Rosa-Neto, P. (2014) Developments in Tau PET Imaging. The Canadian Journal of Neurological Sciences, 41(05), 547-553. DOI: 10.1017/cjn.2014.15  

  • April 26, 2015
  • 11:21 PM

References to alcohol in UK pop music are on the increase

by BPS Research Digest in BPS Research Digest

"My wine is good to me, it helps me pass the time. And my good old buddy whiskey keeps me warmer than the sunshine," Aloe Blacc – I need a dollar, 2011.Psychologists have documented a striking increase in references to alcohol and heavy drinking in the lyrics of UK chart music. They warn this could mean that attempts to control the direct advertising of alcohol to young people will be in vain, as pop music is effectively spreading a positive message on the drinks companies' behalf.Katheri........ Read more »

  • April 26, 2015
  • 03:14 PM

Fatal attraction: the intuitive appeal of GMO opposition

by Dr. Jekyll in Lunatic Laboratories

A team of Belgian philosophers and plant biotechnologists have turned to cognitive science to explain why opposition to genetically modified organisms (GMOs) has become so widespread, despite positive contributions GM crops have made to sustainable agriculture. They argue that the human mind is highly susceptible to the negative and often emotional representations put out by certain environmental groups and other opponents of GMOs. The researchers urge the general public to form opinions on GMOs........ Read more »

Blancke, S., Van Breusegem, F., De Jaeger, G., Braeckman, J., & Van Montagu, M. (2015) Fatal attraction: the intuitive appeal of GMO opposition. Trends in Plant Science. DOI: 10.1016/j.tplants.2015.03.011  

  • April 26, 2015
  • 02:48 PM

Single Pill Combination Therapy For Some Hepatitis C Subtypes

by Marie Benz in Medical Research Interviews and News Interview with: Stefan Zeuzem, MD Professor of Medicine Chief Department of Medicine Goethe University Hospital Frankfurt Medical Research: What is the background for this study? What are the main findings? Dr. Zeuzem: Interferon- and ribavirin-free regimens are needed to … Continue reading →
The post Single Pill Combination Therapy For Some Hepatitis C Subtypes appeared first on Medical ........ Read more » Interview with: Stefan Zeuzem, MD. (2015) Single Pill Combination Therapy For Some Hepatitis C Subtypes. info:/

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